Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort Arthritis & Rheumatism, 04/27/2012

Haroon N et al. – This is the first study to demonstrate that LMP2 variants can affect radiographic severity in ankylosing spondylitis (AS). The baseline mSASSS remains the strongest predictor of radiographic progression but explains only a fraction of the variability seen.

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