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Orthopedics - Clinical Pharmacology News & Articles

MDLinx Orthopedics, your most trusted resource for the latest medical articles! Topics covered range from Bone Metabolism, Foot & Ankle, Shoulder & Elbow, Hip, Knee, Hand & Wrist and much more. Our talented team of orthopedic medical editors vigorously rank, sort and summarize the top peer reviewed medical journals to ensure you receive the most pertinent information.

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Articles

Latest (1) Full Text Articles (32)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

981 A Multi-Center, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients Pain Medicine, July 2, 2010

982 Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty Journal of Clinical Pharmacy and Therapeutics, July 2, 2010

983 Non-pharmacological care for patients with generalized osteoarthritis: design of a randomized clinical trial Full Text BMC Musculoskeletal Disorders, July 2, 2010

984 Negligible Analgesic Tolerance Seen with Extended Release Oxymorphone: A Post Hoc Analysis of Open-Label Longitudinal Data Pain Medicine, July 2, 2010

985 A Cost-Consequence Analysis of Pregabalin versus Usual Care in the Symptomatic Treatment of Refractory Low Back Pain: Sub-Analysis of Observational Trial Data from Orthopaedic Surgery and Rehabilitation Clinics Clinical Drug Investigation, July 2, 2010

986 Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo- and Active-Controlled Phase III Study Clinical Drug Investigation, July 2, 2010

987 Chronic Osteomyelitis in Children: Treatment by Intramedullary Reaming and Antibiotic-impregnated Cement Rods Journal of Pediatric Orthopaedics , July 1, 2010

988 Orthopaedic antimicrobial prophylaxis in the United Kingdom European Journal of Orthopaedic Surgery & Traumatology, July 1, 2010

989 Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain Pain Practice, June 30, 2010

990 Evaluation of study discontinuations with tapentadol immediate release and oxycodone immediate release in patients with low back or osteoarthritis pain Journal of Opioid Management, June 30, 2010

991 A randomized, placebo-controlled, double-blinded, parallel-group, 5-week study of buprenorphine transdermal system in adults with osteoarthritis Journal of Opioid Management, June 30, 2010

992 Injection of Demineralized Bone Matrix With Bone Marrow Concentrate Improves Healing in Unicameral Bone Cyst Clinical Orthopedics and Related Research, June 30, 2010

993 Proton Pump Inhibitors and Histamine-2 Receptor Antagonists Are Associated With Hip Fractures Among At-Risk Patients Gastroenterology, June 30, 2010

994 Passive joint mobilisation: does it enhance outcome of adhesive capsulitis of the shoulder following corticosteroid injection International Musculoskeletal Medicine, June 30, 2010

995 Reduction in Narcotic Use After Primary Total Knee Arthroplasty and Association with Patient Pain Relief and Satisfaction Journal of Arthroplasty, June 29, 2010

996 Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled phase 3 study of postmenopausal women with osteoporosis Full Text BMC Musculoskeletal Disorders, June 29, 2010

997 Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study Bone, June 29, 2010

998 Deep Vein Thrombosis Propylaxis: Better Living Through Chemistry-Affirms Seminars in Arthroplasty, June 29, 2010

999 Deep Vein Thrombosis Prophylaxis: Better Living Through Chemistry-Opposes Seminars in Arthroplasty, June 29, 2010

1000 Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase Clinical Therapeutics, June 28, 2010

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Clinical Pearls in Orthopedics

Highlights in Orthopedics

Zoledronic acid effective in fracture prevention after 1 year of treatment

As reported in the Journal of Bone and Mineral Research, the anti-fracture effect of zoledronic acid is apparent as early as 12 months after treatment and persists for at least 3 years. The study involved 9355 women with osteoporosis who were followed for 3 y. Compared with the placebo group, the ORs for fractures in the women 1, 2, and 3 years after treatment with zoledronic acid were 0.74, 0.53, and 0.61, respectively.

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Exercise + weight loss program effective in treating hip OA

As published in Physical Therapy, a combined 8-month exercise plus weight loss program in overweight or obese patients with hip OA (n=35) resulted in a 32.6% self-reported improvement in physical functioning, as well as pain and walking. This is the first report to demonstrate a benefit in patients with hip OA, which is consistent with the reported benefit of exercise plus weight loss in patients with knee OA.

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An alternative regimen for diabetic foot infections

As published in Infection, iv moxifloxacin (400 mg qd) is as effective as iv piperacillin/tazobactam (4.0/0.5 g tid) followed by oral amoxicillin/clavulanate (875/125 mg bid x 7-21 d) in the treatment of diabetic foot infections (69.9%-76.4% vs. 69.1%-78.8%, respectively).

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Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

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