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Orthopedics - Clinical Pharmacology News & Articles

MDLinx Orthopedics, your most trusted resource for the latest medical articles! Topics covered range from Bone Metabolism, Foot & Ankle, Shoulder & Elbow, Hip, Knee, Hand & Wrist and much more. Our talented team of orthopedic medical editors vigorously rank, sort and summarize the top peer reviewed medical journals to ensure you receive the most pertinent information.

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Your Unread Messages in Orthopedics

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Articles

Latest (1) Full Text Articles (32)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

981 A Multi-Center, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients Pain Medicine, July 2, 2010

982 Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty Journal of Clinical Pharmacy and Therapeutics, July 2, 2010

983 Non-pharmacological care for patients with generalized osteoarthritis: design of a randomized clinical trial Full Text BMC Musculoskeletal Disorders, July 2, 2010

984 Negligible Analgesic Tolerance Seen with Extended Release Oxymorphone: A Post Hoc Analysis of Open-Label Longitudinal Data Pain Medicine, July 2, 2010

985 A Cost-Consequence Analysis of Pregabalin versus Usual Care in the Symptomatic Treatment of Refractory Low Back Pain: Sub-Analysis of Observational Trial Data from Orthopaedic Surgery and Rehabilitation Clinics Clinical Drug Investigation, July 2, 2010

986 Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo- and Active-Controlled Phase III Study Clinical Drug Investigation, July 2, 2010

987 Chronic Osteomyelitis in Children: Treatment by Intramedullary Reaming and Antibiotic-impregnated Cement Rods Journal of Pediatric Orthopaedics , July 1, 2010

988 Orthopaedic antimicrobial prophylaxis in the United Kingdom European Journal of Orthopaedic Surgery & Traumatology, July 1, 2010

989 Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain Pain Practice, June 30, 2010

990 Evaluation of study discontinuations with tapentadol immediate release and oxycodone immediate release in patients with low back or osteoarthritis pain Journal of Opioid Management, June 30, 2010

991 A randomized, placebo-controlled, double-blinded, parallel-group, 5-week study of buprenorphine transdermal system in adults with osteoarthritis Journal of Opioid Management, June 30, 2010

992 Injection of Demineralized Bone Matrix With Bone Marrow Concentrate Improves Healing in Unicameral Bone Cyst Clinical Orthopedics and Related Research, June 30, 2010

993 Proton Pump Inhibitors and Histamine-2 Receptor Antagonists Are Associated With Hip Fractures Among At-Risk Patients Gastroenterology, June 30, 2010

994 Passive joint mobilisation: does it enhance outcome of adhesive capsulitis of the shoulder following corticosteroid injection International Musculoskeletal Medicine, June 30, 2010

995 Reduction in Narcotic Use After Primary Total Knee Arthroplasty and Association with Patient Pain Relief and Satisfaction Journal of Arthroplasty, June 29, 2010

996 Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled phase 3 study of postmenopausal women with osteoporosis Full Text BMC Musculoskeletal Disorders, June 29, 2010

997 Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study Bone, June 29, 2010

998 Deep Vein Thrombosis Propylaxis: Better Living Through Chemistry-Affirms Seminars in Arthroplasty, June 29, 2010

999 Deep Vein Thrombosis Prophylaxis: Better Living Through Chemistry-Opposes Seminars in Arthroplasty, June 29, 2010

1000 Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase Clinical Therapeutics, June 28, 2010

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Clinical Pearls in Orthopedics

Highlights in Orthopedics

Zoledronic acid effective in fracture prevention after 1 year of treatment

As reported in the Journal of Bone and Mineral Research, the anti-fracture effect of zoledronic acid is apparent as early as 12 months after treatment and persists for at least 3 years. The study involved 9355 women with osteoporosis who were followed for 3 y. Compared with the placebo group, the ORs for fractures in the women 1, 2, and 3 years after treatment with zoledronic acid were 0.74, 0.53, and 0.61, respectively.

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Exercise + weight loss program effective in treating hip OA

As published in Physical Therapy, a combined 8-month exercise plus weight loss program in overweight or obese patients with hip OA (n=35) resulted in a 32.6% self-reported improvement in physical functioning, as well as pain and walking. This is the first report to demonstrate a benefit in patients with hip OA, which is consistent with the reported benefit of exercise plus weight loss in patients with knee OA.

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An alternative regimen for diabetic foot infections

As published in Infection, iv moxifloxacin (400 mg qd) is as effective as iv piperacillin/tazobactam (4.0/0.5 g tid) followed by oral amoxicillin/clavulanate (875/125 mg bid x 7-21 d) in the treatment of diabetic foot infections (69.9%-76.4% vs. 69.1%-78.8%, respectively).

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Most Popular Orthopedics Articles

Last month's top read Top Articles of 2012

1 The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction Knee Surgery, Sports Traumatology, Arthroscopy, April 22, 2013

2 The Efficacy and Safety of Bisphosphonates for Osteoporosis or Osteopenia in Crohns Disease: A Meta-Analysis Digestive Diseases and Sciences, April 19, 2013    Evidence Based Medicine

3 Comparison of Teriparatide and Bisphosphonate Treatment to Reduce Pedicle Screw Loosening After Lumbar Spinal Fusion Surgery in Postmenopausal Women With Osteoporosis From a Bone Quality Perspective Spine, April 16, 2013    Evidence Based Medicine

4 Tanezumab reduces osteoarthritic hip pain: Results of a randomized, double-blind, placebo-controlled phase 3 trial Arthritis & Rheumatism, April 2, 2013

5 Effects of Combined Application of Muscle Relaxants and Celecoxib Administration After Total Knee Arthroplasty (TKA) on Early Recovery: A Randomized, Double-Blind, Controlled Study Journal of Arthroplasty, April 8, 2013

6 Long-lasting beneficial effects of periradicular injection of meloxicam for treating chronic low back pain and sciatica Minerva Anestesiologica, April 5, 2013    Free full text

7 A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis Rheumatology, April 1, 2013

8 Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone Journal of Back and Musculoskeletal Rehabilitation, March 21, 2013

9 Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial Canadian Journal of Anesthesia, March 13, 2013

10 Impact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial British Medical Journal, April 26, 2013    Evidence Based Medicine

11 Target-controlled infusion (Propofol) versus inhaled anaesthetic (Sevoflurane) in patients undergoing shoulder arthroscopic surgery Indian Journal of Anaesthesia, April 12, 2013    Free full text

12 Is discontinuation of clopidogrel necessary for intracapsular hip fracture surgery? Analysis of 102 hemiarthroplasties Journal of Orthopaedics and Traumatology, April 10, 2013    Free full text    Evidence Based Medicine

13 I.V. and perineural dexamethasone are equivalent in increasing the analgesic duration of a single-shot interscalene block with ropivacaine for shoulder surgery: a prospective, randomized, placebo-controlled study British Journal of Anesthesia, April 17, 2013

14 Steroid injections in the treatment of humeral unicameral bone cysts: long-term follow-up and review of the literature European Journal of Orthopaedic Surgery & Traumatology, April 10, 2013    Evidence Based Medicine

15 Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative Annals of Rheumatic Diseases, April 23, 2013

16 Antimicrobial Peptides and Proinflammatory Cytokines in Periprosthetic Joint Infection The Journal of Bone & Joint Surgery, April 4, 2013    Evidence Based Medicine

17 Results of infected total knee arthroplasty treated with arthroscopic debridement and continuous antibiotic irrigation system Indian Journal of Orthopaedics, February 14, 2013    Free full text

18 Economic Evaluation of Chlorhexidine Cloths on Healthcare Costs due to Surgical Site Infections Following Total Knee Arthroplasty Journal of Arthroplasty, April 3, 2013    Review Article

19 Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain Pain, March 14, 2013

20 Backfilling of iliac crest defects with hydroxyapatite-calcium triphosphate biphasic compound: a prospective, randomized computed tomography and patient-based analysis The Spine Journal, February 13, 2013

Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

Other Topics in Orthopedics

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