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Orthopedics - Clinical Pharmacology News & Articles

MDLinx Orthopedics, your most trusted resource for the latest medical articles! Topics covered range from Bone Metabolism, Foot & Ankle, Shoulder & Elbow, Hip, Knee, Hand & Wrist and much more. Our talented team of orthopedic medical editors vigorously rank, sort and summarize the top peer reviewed medical journals to ensure you receive the most pertinent information.

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Your Unread Messages in Orthopedics

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Articles

Latest (6) Full Text Articles (32)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

921 Acute Effects of Intravenous Administration of Pamidronate in Patients with Osteoporosis Full Text Journal of Korean Medical Science, August 18, 2010    Clinical Article

922 Impact of Steroids on Surgical Experiences of Patients With Duchenne Muscular Dystrophy Pediatric Neurology , August 18, 2010

923 Tramadol/Paracetamol Fixed-Dose Combination: A Review of its Use in the Management of Moderate to Severe Pain Clinical Drug Investigation, August 17, 2010

924 Increased Chondrocyte Death after Steroid and Local Anesthetic Combination Clinical Orthopedics and Related Research, August 17, 2010

925 The course of opioid prescribing for a new episode of disabling low back pain: Opioid features and dose escalation Pain, August 16, 2010

926 Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules in Patients with Chronic Osteoarthritis Pain Postgraduate Medicine, August 12, 2010

927 A meta-analysis of the efficacy of raloxifene on all clinical and vertebral fractures and its dependency on FRAX Bone, August 12, 2010

928 Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate Bone, August 12, 2010

929 Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice Thrombosis and Haemostasis, August 12, 2010

930 Pharmacologic Intervention for Osteoarthritis in Older Adults Clinics in Geriatric Medicine, August 11, 2010

931 Current concepts in corticosteroid-induced bone disease Full Text The Journal of Musculoskeletal Medicine, August 11, 2010

932 Evidence on the Effectiveness of Topical Nitroglycerin in the Treatment of Tendinopathies: A Systematic Review and Meta-Analysis Archives of Physical Medicine and Rehabilitation, August 11, 2010    Evidence Based Medicine

933 The effect of injections of botulinum toxin type A combined with casting on the equinus gait of children with cerebral palsy The Bone & Joint Journal, August 11, 2010

934 A systematic review assessing the effectiveness of interventions to improve persistence with anti-resorptive therapy in women at high risk of clinical fracture Family Practice, August 10, 2010    Evidence Based Medicine

935 A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain Full Text European Spine Journal, August 6, 2010    Evidence Based Medicine

936 How to prevent glucocorticoid-induced osteoporosis Full Text Cleveland Clinic Journal of Medicine, August 6, 2010    Continuing Medical Education
Exclusive Author Commentary

937 Can clodronate be effective in the treatment of disabling hydroxyapatite crystal-deposition disease : A report of two cases Rheumatology International, August 6, 2010

938 Musculoskeletal pain: prescription of NSAID and weak opioid by primary health care physicians in Sweden 2004–2008 – a retrospective patient record review Full Text Journal of Pain Research, August 5, 2010
Exclusive Author Commentary

939 Dynamic Nature of the Placebo Response Journal of Orthopaedic & Sports Physical Therapy, August 5, 2010

940 Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study Breast Cancer Research and Treatment, August 4, 2010
Exclusive Author Commentary

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Clinical Pearls in Orthopedics

Highlights in Orthopedics

Zoledronic acid effective in fracture prevention after 1 year of treatment

As reported in the Journal of Bone and Mineral Research, the anti-fracture effect of zoledronic acid is apparent as early as 12 months after treatment and persists for at least 3 years. The study involved 9355 women with osteoporosis who were followed for 3 y. Compared with the placebo group, the ORs for fractures in the women 1, 2, and 3 years after treatment with zoledronic acid were 0.74, 0.53, and 0.61, respectively.

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Exercise + weight loss program effective in treating hip OA

As published in Physical Therapy, a combined 8-month exercise plus weight loss program in overweight or obese patients with hip OA (n=35) resulted in a 32.6% self-reported improvement in physical functioning, as well as pain and walking. This is the first report to demonstrate a benefit in patients with hip OA, which is consistent with the reported benefit of exercise plus weight loss in patients with knee OA.

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An alternative regimen for diabetic foot infections

As published in Infection, iv moxifloxacin (400 mg qd) is as effective as iv piperacillin/tazobactam (4.0/0.5 g tid) followed by oral amoxicillin/clavulanate (875/125 mg bid x 7-21 d) in the treatment of diabetic foot infections (69.9%-76.4% vs. 69.1%-78.8%, respectively).

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Most Popular Orthopedics Articles

Last month's top read Top Articles of 2012

1 The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction Knee Surgery, Sports Traumatology, Arthroscopy, April 22, 2013

2 The Efficacy and Safety of Bisphosphonates for Osteoporosis or Osteopenia in Crohns Disease: A Meta-Analysis Digestive Diseases and Sciences, April 19, 2013    Evidence Based Medicine

3 Comparison of Teriparatide and Bisphosphonate Treatment to Reduce Pedicle Screw Loosening After Lumbar Spinal Fusion Surgery in Postmenopausal Women With Osteoporosis From a Bone Quality Perspective Spine, April 16, 2013    Evidence Based Medicine

4 Tanezumab reduces osteoarthritic hip pain: Results of a randomized, double-blind, placebo-controlled phase 3 trial Arthritis & Rheumatism, April 2, 2013

5 Effects of Combined Application of Muscle Relaxants and Celecoxib Administration After Total Knee Arthroplasty (TKA) on Early Recovery: A Randomized, Double-Blind, Controlled Study Journal of Arthroplasty, April 8, 2013

6 Long-lasting beneficial effects of periradicular injection of meloxicam for treating chronic low back pain and sciatica Minerva Anestesiologica, April 5, 2013    Free full text

7 A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis Rheumatology, April 1, 2013

8 Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone Journal of Back and Musculoskeletal Rehabilitation, March 21, 2013

9 Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial Canadian Journal of Anesthesia, March 13, 2013

10 Impact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial British Medical Journal, April 26, 2013    Evidence Based Medicine

11 Target-controlled infusion (Propofol) versus inhaled anaesthetic (Sevoflurane) in patients undergoing shoulder arthroscopic surgery Indian Journal of Anaesthesia, April 12, 2013    Free full text

12 Is discontinuation of clopidogrel necessary for intracapsular hip fracture surgery? Analysis of 102 hemiarthroplasties Journal of Orthopaedics and Traumatology, April 10, 2013    Free full text    Evidence Based Medicine

13 I.V. and perineural dexamethasone are equivalent in increasing the analgesic duration of a single-shot interscalene block with ropivacaine for shoulder surgery: a prospective, randomized, placebo-controlled study British Journal of Anesthesia, April 17, 2013

14 Steroid injections in the treatment of humeral unicameral bone cysts: long-term follow-up and review of the literature European Journal of Orthopaedic Surgery & Traumatology, April 10, 2013    Evidence Based Medicine

15 Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative Annals of Rheumatic Diseases, April 23, 2013

16 Antimicrobial Peptides and Proinflammatory Cytokines in Periprosthetic Joint Infection The Journal of Bone & Joint Surgery, April 4, 2013    Evidence Based Medicine

17 Results of infected total knee arthroplasty treated with arthroscopic debridement and continuous antibiotic irrigation system Indian Journal of Orthopaedics, February 14, 2013    Free full text

18 Economic Evaluation of Chlorhexidine Cloths on Healthcare Costs due to Surgical Site Infections Following Total Knee Arthroplasty Journal of Arthroplasty, April 3, 2013    Review Article

19 Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain Pain, March 14, 2013

20 Backfilling of iliac crest defects with hydroxyapatite-calcium triphosphate biphasic compound: a prospective, randomized computed tomography and patient-based analysis The Spine Journal, February 13, 2013

Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

Other Topics in Orthopedics

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