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Orthopedics - Clinical Pharmacology News & Articles

MDLinx Orthopedics, your most trusted resource for the latest medical articles! Topics covered range from Bone Metabolism, Foot & Ankle, Shoulder & Elbow, Hip, Knee, Hand & Wrist and much more. Our talented team of orthopedic medical editors vigorously rank, sort and summarize the top peer reviewed medical journals to ensure you receive the most pertinent information.

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Articles

Latest (2) Full Text Articles (32)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

801 Influence of timing and oral anticoagulant/antiplatelet therapy on outcomes of patients affected by hip fractures European Journal of Trauma and Emergency Surgery, February 3, 2011

802 Botulinum toxin injections for low-back pain and sciatica Cochrane Reviews, February 2, 2011

803 Biodegradable antibiotic delivery systems The Bone & Joint Journal, February 1, 2011    Clinical Article

804 One-Year Results of a Randomized, Double-Blind, Active Controlled Trial of Fluoroscopic Caudal Epidural Injections With or Without Steroids in Managing Chronic Discogenic Low Back Pain Without Disc Herniation or Radiculitis Full Text Pain Physician, January 31, 2011    Clinical Article

805 Ten-Year Follow-Up of Avascular Necrosis of Femoral Head Treated With Alendronate for 3 Years Journal of Arthroplasty, January 28, 2011    Clinical Article

806 Low-Dose, Low-Concentration Levobupivacaine Plus Fentanyl Selective Spinal Anesthesia for Knee Arthroscopy: A Dose Finding Study Anesthesia & Analgesia, January 28, 2011    Clinical Article

807 Meta-analysis: Risk of fractures with acid-suppressing medication Bone, January 27, 2011    Evidence Based Medicine

808 Failed Back Surgery Syndrome and intrathecal drugs infusion European Journal of Pain Supplements, January 27, 2011

809 The Asthmatic Athlete: Inhaled Beta-2 Agonists, Sport Performance, and Doping Clinical Journal of Sport Medicine, January 25, 2011

810 Long-term follow-up of adalimumab monotherapy for rheumatoid arthritis in Japanese patients: a report of six cases Rheumatology International, January 25, 2011

811 Fostamatinib, a Syk-Kinase Inhibitor, Does Not Affect Methotrexate Pharmacokinetics in Patients With Rheumatoid Arthritis The Journal of Clinical Pharmacology, January 24, 2011    Clinical Article

812 Bisphosphonates for post-menopausal osteoporosis: are they all the same QJM: An International Journal of Medicine, January 24, 2011    Clinical Article

813 Management of osteoporosis in men on androgen deprivation therapy Maturitas, January 24, 2011

814 Safety and efficacy of an oral histone deacetylase inhibitor in systemic onset juvenile idiopathic arthritis Arthritis & Rheumatism, January 20, 2011    Clinical Article

815 Anti-infliximab antibodies are already detectable in most patients with rheumatoid arthritis halfway through an infusioncycle: an open-label pharmacokinetic cohort study Full Text BMC Musculoskeletal Disorders, January 20, 2011    Clinical Article

816 The effect of endoskeleton on antibiotic impregnated cement spacer for treating deep hip infection Full Text BMC Musculoskeletal Disorders, January 19, 2011    Clinical Article

817 Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFalpha therapy medication Full Text BMC Musculoskeletal Disorders, January 19, 2011    Clinical Article

818 Secondary failure to treatment with recombinant human IL-1 receptor antagonist in Chinese patients with rheumatoid arthritis Clinical Rheumatology, January 19, 2011    Clinical Article

819 Frontline treatment of localized osteosarcoma without methotrexate Cancer, January 18, 2011    Clinical Article

820 A 3 mg/kg starting dose of infliximab in active spondyloarthritis resistant to conventional treatments is efficient, safe and lowers costs Joint, Bone, Spine, January 18, 2011    Clinical Article

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Clinical Pearls in Orthopedics

Highlights in Orthopedics

Zoledronic acid effective in fracture prevention after 1 year of treatment

As reported in the Journal of Bone and Mineral Research, the anti-fracture effect of zoledronic acid is apparent as early as 12 months after treatment and persists for at least 3 years. The study involved 9355 women with osteoporosis who were followed for 3 y. Compared with the placebo group, the ORs for fractures in the women 1, 2, and 3 years after treatment with zoledronic acid were 0.74, 0.53, and 0.61, respectively.

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Exercise + weight loss program effective in treating hip OA

As published in Physical Therapy, a combined 8-month exercise plus weight loss program in overweight or obese patients with hip OA (n=35) resulted in a 32.6% self-reported improvement in physical functioning, as well as pain and walking. This is the first report to demonstrate a benefit in patients with hip OA, which is consistent with the reported benefit of exercise plus weight loss in patients with knee OA.

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An alternative regimen for diabetic foot infections

As published in Infection, iv moxifloxacin (400 mg qd) is as effective as iv piperacillin/tazobactam (4.0/0.5 g tid) followed by oral amoxicillin/clavulanate (875/125 mg bid x 7-21 d) in the treatment of diabetic foot infections (69.9%-76.4% vs. 69.1%-78.8%, respectively).

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Most Popular Orthopedics Articles

Last month's top read Top Articles of 2012

1 The influence of steroid administration on systemic response in laminoplasty for cervical myelopathy Archives of Orthopaedic and Trauma Surgery, May 6, 2013    Evidence Based Medicine

2 Efficacy of duloxetine versus alternative oral therapies: an indirect comparison of randomised clinical trials in chronic low back pain European Spine Journal, May 20, 2013    Evidence Based Medicine

3 Nonbenzodiazepine Sleep Medication Use and Hip Fractures in Nursing Home Residents JAMA Internal Medicine, May 15, 2013    Evidence Based Medicine

4 Thalidomide reduces recurrence of ankylosing spondylitis in patients following discontinuation of etanercept Rheumatology International, May 28, 2013

5 Bisphosphonate-related osteonecrosis of the jaw in non-malignant bone disease Rheumatology International, May 9, 2013

6 Topical glyceryl trinitrate treatment of chronic patellar tendinopathy: a randomised, double blind, placebo controlled clinical trial British Journal of Sports Medicine, May 29, 2013    Evidence Based Medicine

7 Cost-Effectiveness of Duloxetine in Chronic Low Back Pain: A Quebec Societal Perspective Spine, May 17, 2013    Evidence Based Medicine

8 Efficacy of continuous subacromial bupivacaine infusion for pain control after arthroscopic rotator cuff repair Journal of Shoulder and Elbow Surgery, May 14, 2013    Evidence Based Medicine

9 Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma European Journal of Cancer, May 10, 2013

10 Controlled-release oxycodone and naloxone in the treatment of chronic low back pain: A placebo-controlled, randomized study, Pain Research and Management, May 24, 2013

11 Tolerability of diclofenac sodium 1% gel with concomitant medications known to interact with diclofenac Therapeutics and Clinical Risk Management, May 3, 2013    Free full text

12 Effects of Combined Application of Muscle Relaxants and Celecoxib Administration After Total Knee Arthroplasty (TKA) on Early Recovery: A Randomized, Double-Blind, Controlled Study Journal of Arthroplasty, April 9, 2013

13 Cost-effectiveness of exercise therapy after corticosteroid injection for moderate to severe shoulder pain due to subacromial impingement syndrome: a trial-based analysis Rheumatology, May 1, 2013

14 Effects of vancomycin, cefazolin and test conditions on the wear behavior of bone cement Journal of Arthroplasty, May 23, 2013

15 Methylprednisolone Injections for the Treatment of Morton Neuroma A Patient-Blinded Randomized Trial The Journal of Bone & Joint Surgery, May 3, 2013    Evidence Based Medicine

16 Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial Annals of Rheumatic Diseases, May 8, 2013

17 Patient experiences, attitudes and expectations towards receiving information about anti-TNF medication -- "It could give me two heads and I'd still try it!" BMC Musculoskeletal Disorders, May 13, 2013    Free full text    Evidence Based Medicine

18 Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial Canadian Journal of Anesthesia, March 13, 2013

19 Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone Journal of Back and Musculoskeletal Rehabilitation, March 21, 2013

20 A phase III placebo- and oxycodone-controlled study of tanezumab in adults with osteoarthritis pain of the hip or knee Pain, April 30, 2013

Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

Other Topics in Orthopedics

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