Interdependence of muscle atrophy and bone loss induced by mechanical unloading

Journal of Bone and Mineral Research, 10/28/2013

Mechanical unloading induces muscle atrophy and bone loss; however, the time course and interdependence of these effects is not well defined. Trabecular bone loss with age, similar to that which occurs in mature astronauts, is superimposed on unloading. Preservation of muscle mass, cortical structure, and bone strength during the experiment suggests muscle may have a greater effect on cortical than trabecular bone.

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