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Temporal trends in obesity, osteoporosis treatment, bone mineral density and fracture rates: A population-based historical cohort study
Journal of Bone and Mineral Research,  Clinical Article

Leslie WD et al. – Diverging international trends in fracture rates have been observed, with most reports showing that fracture rates have stabilized or decreased in North American and many European populations. Major osteoporotic fracture rates declined substantially and linearly from 1996 to 2006, and this was explained by improvements in BMD rather than greater rates of obesity or osteoporosis treatment.

Methods

  • The authors studied two complementary population-based historical cohorts from the Province of Manitoba, Canada (1996–2006) to determine whether declining osteoporotic fracture rates in Canada are attributable to trends in obesity, osteoporosis treatment, or bone mineral density (BMD).
  • The Population Fracture Registry included women age 50-years and older with major osteoporotic fractures, and was used to assess impact of changes in osteoporosis treatment.
  • The BMD Registry included all women age 50-years and older undergoing BMD tests, and was used to assess impact of changes in obesity and BMD.
  • Model-based estimates of temporal changes in fracture rates (Fracture Registry) were calculated.
  • Temporal changes in obesity and BMD and their association with fracture rates (BMD Registry) were estimated.

Results

  • In the Fracture Registry (N = 27,341), fracture rates declined -1.6% per year (95% CI, -1.3% to -2.0%).
  • Although osteoporosis treatment increased from 5.6% to 17.4%, the decline in fractures was independent of osteoporosis treatment.
  • In the BMD Registry (N = 36,587), obesity increased from 12.7% to 27.4%.
  • Femoral neck BMD increased 0.52% per year and lumbar spine BMD increased 0.32% per year after covariate adjustment (p < 0.001).
  • Major osteoporotic fracture rates decreased in models that did not include femoral neck BMD (fully adjusted annual change -1.8%, 95%CI, -2.9 to -0.5), but adjusting for femoral neck BMD accounted for the observed reduction (annual change -0.5%, 95%CI, -1.8 to +1.0).

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