Sclerostin and bone strength in women in their 10th decade of life

Journal of Bone and Mineral Research, 03/18/2013

Sclerostin is a potent inhibitor of bone formation but has been shown to correlate positively with areal bone mineral density (aBMD). Little is known about its relationship to parameters of bone strength and volumentric BMD (vBMD) as measured by peripheral quantitative computed tomography (pQCT). The results suggest paradoxical associations between circulating sclerostin and bone size, density and strength.

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