Structure and strength of the distal radius in female patients with rheumatoid arthritis: A case-control study

Journal of Bone and Mineral Research, 02/12/2013

The study aims to investigate volumetric bone mineral density (vBMD), bone microstructure and mechanical indices of the distal radius in female patients with rheumatoid arthritis (RA). HR–pQCT provides new insight into inflammation–associated bone fragility in RA. It detects differences in vBMD, bone microstructure and mechanical indices that are not captured by DXA. At the distal radius, deterioration in density and microstructure in RA patients involved both cortical and trabecular compartments. Excessive bone resorption appears to affect cortical more than trabecular bone at distal radius, particularly manifested as increased cortical porosity. Ulnovolar periosteal apposition of the distal radius is a feature of chronic, severe RA with wrist deformity.

Print Article Summary