Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage

Journal of Bone and Mineral Research, 02/22/2013

It is largely unknown whether osteoarthritis (OA) is associated with alterations in the epigenetic status of anabolic factors. The findings suggest that hip OA is associated with a change in the epigenetic status of SOX–9 promoter including increased DNA methylation and altered histone modification.

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