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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
Therapeutic Advances in Musculoskeletal Disease, 06/04/2012
Goldring MB – Since the chondrocytes in adult human cartilage are normally quiescent and maintain the matrix in a low turnover state, understanding how they undergo phenotypic modulation and promote matrix destruction and abnormal repair in osteoarthritis (OA) may to lead to identification of critical targets for therapy to block cartilage damage and promote effective cartilage repair.
