Impact of statin discontinuation on mortality in patients with rheumatoid arthritis - A population-based study
Arthritis Care & Research ,  Clinical Article

De Vera MA et al. – These population–based data indicate that statin discontinuation in rheumatoid arthritis (RA) patients is associated with increased risk of death from cardiovascular disease and all causes. Findings provide support for the importance of compliance with therapy in RA patients who are prescribed statins.

Methods
  • The authors conducted a population–based longitudinal study of RA patients with incident statin use followed from 1996 to 2006 using administrative health data.
  • Statin discontinuation was defined as persistent non–use ≥3 months during therapy course.
  • Primary outcomes were mortality from all cardiovascular diseases (CVD mortality) and secondary outcomes were deaths from all causes (all cause mortality).
  • Cox's proportional hazards models, with statin discontinuation as a time–dependent variable, were used and multivariable models were adjusted for age, sex, comorbidities and risk factors for mortality, and proxy indicators of RA severity.

Results
  • Over 16,144 person–years of follow–up in the cohort of 4,102 incident statin users, they documented 198 deaths due to CVD and 467 deaths overall.
  • Adjusted hazard ratios (HR) for the association of statin discontinuation with death were 1.60 (95% CI: 1.15–2.23) for CVD mortality and 1.79 (95% CI: 1.46–2.20) for all cause mortality.
  • The association between statin discontinuation and mortality outcomes was not modified by timing of first statin prescription, age, and sex (p–values for interaction: >0.29).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Orthopedics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Orthopedics Articles

1 New research: Arthritis medicine linked to deaths Aarhus University Health News, November 17, 2014

2 Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: A double-blind, randomized, controlled, noninferiority clinical trial The Journal of Bone & Joint Surgery, December 12, 2014    Clinical Article

3 Common knee surgery may lead to arthritis and cartilage loss Radiological Society of North America News, December 5, 2014

4 Non-steroidal anti-inflammatory drugs versus corticosteroid for treatment of shoulder pain: A systematic review and meta-analysis Archives of Physical Medicine and Rehabilitation, May 19, 2014    Evidence Based Medicine    Review Article    Clinical Article

5 Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety BMJ, September 9, 2014    Evidence Based Medicine    Clinical Article

6 Effectiveness of tranexamic acid in reducing blood loss in spinal surgery: a meta-analysis Full Text BMC Musculoskeletal Disorders, December 24, 2014    Free full text

7 Wintertime surgery increases the risk of conversion to hip arthroplasty after internal fixation of femoral neck fracture Osteoporosis International, December 19, 2014    Clinical Article

8 A randomized double-blind clinical trial on the treatment of knee osteoarthritis: The efficacy of polynucleotides compared to standard hyaluronian viscosupplementation The Knee, April 7, 2014    Evidence Based Medicine    Clinical Article

9 Stop that scalpel: Many kids with open bone breaks can heal safely without surgery Johns Hopkins Medicine, December 12, 2014

10 New hope for patients with Complex Regional Pain Syndrome University of Liverpool News, December 9, 2014

11 Results of lumbar endoscopic adhesiolysis using a radiofrequency catheter in patients with postoperative fibrosis and persistent or recurrent symptoms after discectomy Pain Practice, December 4, 2014    Clinical Article

12 Milk intake and risk of mortality and fractures in women and men: cohort studies BMJ, November 11, 2014    Evidence Based Medicine    Clinical Article

13 A randomized trial of epidural glucocorticoid injections for spinal stenosis Full Text New England Journal of Medicine, July 7, 2014    Free full text    Evidence Based Medicine    Clinical Article

14 Effect of physical therapy on pain and function in patients with hip osteoarthritis: A randomized clinical trial Full Text JAMA, May 21, 2014    Free full text    Evidence Based Medicine    Clinical Article

15 Pulsed radiofrequency of the composite nerve supply to the knee joint as a new technique for relieving osteoarthritic pain: a preliminary report Full Text Pain Physician, December 2, 2014    Free full text    Clinical Article

16 The relationship between pain and eating among overweight and obese individuals with osteoarthritis: An ecological momentary study Pain Research and Management, December 17, 2014    Clinical Article

17 Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials Journal of Bone and Mineral Research, December 9, 2014    Evidence Based Medicine    Clinical Article

18 Role of vitamin D3 in treatment of lumbar disc herniation--pain and sensory aspects: study protocol for a randomized controlled trial Full Text Trials, October 15, 2014    Free full text    Evidence Based Medicine    Clinical Article

19 Association between loop diuretic use and fracture risk Osteoporosis International, December 16, 2014    Clinical Article

20 Operative versus non-operative treatment for closed, displaced, intra-articular fractures of the calcaneus: randomised controlled trial BMJ, August 1, 2014    Clinical Article

Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

Looking for a physician job? Let us help!

Register now for our free job placement service.
A career consultant will contact you soon.
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List