Impact of statin discontinuation on mortality in patients with rheumatoid arthritis - A population-based study
Arthritis Care & Research ,  Clinical Article

De Vera MA et al. – These population–based data indicate that statin discontinuation in rheumatoid arthritis (RA) patients is associated with increased risk of death from cardiovascular disease and all causes. Findings provide support for the importance of compliance with therapy in RA patients who are prescribed statins.

Methods
  • The authors conducted a population–based longitudinal study of RA patients with incident statin use followed from 1996 to 2006 using administrative health data.
  • Statin discontinuation was defined as persistent non–use ≥3 months during therapy course.
  • Primary outcomes were mortality from all cardiovascular diseases (CVD mortality) and secondary outcomes were deaths from all causes (all cause mortality).
  • Cox's proportional hazards models, with statin discontinuation as a time–dependent variable, were used and multivariable models were adjusted for age, sex, comorbidities and risk factors for mortality, and proxy indicators of RA severity.

Results
  • Over 16,144 person–years of follow–up in the cohort of 4,102 incident statin users, they documented 198 deaths due to CVD and 467 deaths overall.
  • Adjusted hazard ratios (HR) for the association of statin discontinuation with death were 1.60 (95% CI: 1.15–2.23) for CVD mortality and 1.79 (95% CI: 1.46–2.20) for all cause mortality.
  • The association between statin discontinuation and mortality outcomes was not modified by timing of first statin prescription, age, and sex (p–values for interaction: >0.29).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Orthopedics

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Orthopedics Articles

1 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

2 Non-steroidal anti-inflammatory drugs versus corticosteroid for treatment of shoulder pain: A systematic review and meta-analysis Archives of Physical Medicine and Rehabilitation, May 19, 2014    Evidence Based Medicine    Review Article    Clinical Article

3 Is statin use associated with new joint-related symptoms, physical function and quality of life? The Australian Longitudinal Study on Womens Health Arthritis Care & Research , July 8, 2014    Clinical Article

4 45-day mortality after 467 779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

5 Wrist-ankle acupuncture for the treatment of pain symptoms: A systematic review and meta-analysis Full Text Evidence-based Complementary and Alternative Medicine , July 18, 2014    Free full text    Evidence Based Medicine    Review Article    Clinical Article

6 Vegetarian diets and bone status American Journal of Clinical Nutrition, June 19, 2014    Clinical Article

7 The functional consequences of Generalized Joint Hypermobility: a cross-sectional study Full Text BMC Musculoskeletal Disorders, July 24, 2014    Free full text    Evidence Based Medicine    Clinical Article

8 Relation between surgeon volume and risk of complications after total hip arthroplasty: propensity score matched cohort study BMJ, June 10, 2014    Evidence Based Medicine    Clinical Article

9 Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study BMJ, July 3, 2014    Evidence Based Medicine    Clinical Article

10 A randomized double-blind clinical trial on the treatment of knee osteoarthritis: The efficacy of polynucleotides compared to standard hyaluronian viscosupplementation The Knee, April 7, 2014    Evidence Based Medicine    Clinical Article

11 Implications of expanding indications for drug treatment to prevent fracture in older men in United States: cross sectional and longitudinal analysis of prospective cohort study BMJ, July 11, 2014    Evidence Based Medicine    Clinical Article

12 Voluntary driven exoskeleton as a new tool for rehabilitation in chronic spinal cord Injury : A pilot study The Spine Journal, July 28, 2014    Evidence Based Medicine    Clinical Article

13 Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

14 Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders Full Text BMC Musculoskeletal Disorders, July 15, 2014    Free full text    Evidence Based Medicine    Clinical Article

15 Local anaesthetic infiltration for peri-operative pain control in total hip and knee replacement: systematic review and meta-analyses of short- and long-term effectiveness Full Text BMC Musculoskeletal Disorders, July 7, 2014    Free full text    Evidence Based Medicine    Clinical Article

16 Trends in the incidence and in-hospital outcomes of elective major orthopaedic surgery in patients eighty years of age and older in the United States from 2000 to 2009 The Journal of Bone & Joint Surgery, July 23, 2014    Evidence Based Medicine    Clinical Article

17 The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010 Osteoporosis International, July 9, 2014    Clinical Article

18 A retrospective comparative study with historical control to determine the effectiveness of platelet-rich plasma as part of nonoperative treatment of acute achilles tendon rupture Arthroscopy, July 7, 2014    Evidence Based Medicine

19 Living with a symptomatic rotator cuff tear 'bad days, bad nights': a qualitative study Full Text BMC Musculoskeletal Disorders, July 15, 2014    Free full text    Evidence Based Medicine    Clinical Article

20 Statins and physical activity in older men the osteoporotic fractures in men study JAMA Internal Medicine, June 12, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Orthopedics: Journal of Bone and Joint Surgery, Journal of Arthroplasty, Spine, The Kneemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close