Pathophysiology of peri-articular bone changes in osteoarthritis
Weinans H et al. – Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri–articular bone are an integral part of the osteoarthritis (OA) disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review the authors try to provide an overview of the current knowledge of peri–articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression.