Growth from birth to adulthood and bone phenotype in early old age: A British birth cohort study

Journal of Bone and Mineral Research, 06/13/2013

There is growing evidence that early growth influences bone mass in later life but most studies are limited to birth weight and/ or early infant growth and DXA measurements. In a British birth cohort study with prospective measures of lifetime height and weight, the authors investigated the growth trajectory in relation to bone in males (M) and females (F) at 60–64 years. In a cohort born in the early post war period, higher birth weight, gaining weight and height faster than others, particularly through the pre–pubertal and post–pubertal periods, was positively related to bone strength, mostly through greater bone CSA, at 60–64 years.

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