X-ray verified fractures are associated with finite element analysis derived bone strength and trabecular microstructure in young adult men

Journal of Bone and Mineral Research, 05/09/2013

The aim of this cross–sectional, population–based study was to investigate whether prevalent fractures, occurring from birth to young adulthood, were related to HR–pQCT derived trabecular and cortical microstructure, and bone strength estimated by finite element (FEA) analysis of the radius and tibia, in 833 young adult men around the time of peak bone mass (23–25 yrs). Prevalent fractures in young adult men were associated with impaired trabecular BV/TV at the radius, independently of aBMD and cortical thickness, indicating that primarily trabecular bone deficits are of greatest importance for prevalent fracture in this population.

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