Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage
Journal of Bone and Mineral Research, 02/22/2013Kim KI et al.
It is largely unknown whether osteoarthritis (OA) is associated with alterations in the epigenetic status of anabolic factors. The findings suggest that hip OA is associated with a change in the epigenetic status of SOX–9 promoter including increased DNA methylation and altered histone modification.
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