Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor

Clinics in Orthopedic Surgery, 06/08/2012

This model represents a self–sufficient osteoclastogenic paracrine loop in a localized area. Consistent with this paradigm, a recombinant RANK–Fc protein and bisphosphonates are currently being tried for giant cell tumor treatment in addition to surgical excision and conventional topical adjuvant therapies.

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