Effectiveness of Nigella sativa Oil in the Management of Rheumatoid Arthritis Patients: A Placebo Controlled Study

Phytotherapy Research, 05/04/2012

Gheita TA et al. – Supplementation with Nigella sativa during DMARD therapy in RA may be considered an affordable potential adjuvant biological therapy.

Methods

  • Data from 40 female RA patients diagnosed according to the 2010 ACR/EULAR were analysed and discussed.
  • The patients took two placebo (starch filled) capsules daily for 1month.
  • This was followed by a month of Nigella sativa oil capsules 500 mg twice/day.

Results

  • The disease activity score (DAS–28) significantly decreased after receiving the Nigella sativa capsules (4.55 ± 0.82) compared with before and after placebo (4.98 ± 0.79 and 4.99 ± 0.72, respectively) (p = 0.017).
  • Similarly, the number of swollen joints and the duration of morning stiffness improved.
  • A marked improvement in the disease activity was shown by both the ACR20 and EULAR response criteria in 42.5% and 30% of the patients, respectively, after intake of Nigella.

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