Effect of TENS on pain in relation to central sensitization in patients with osteoarthritis of the knee: study protocol for a randomized controlled trial
Beckwee D et al. – To increase treatment effectiveness it might be interesting to identify a subgroup of symptomatic knee osteoarthritis (OAk) patients, i.e., non–sensitized patients, who are likely to benefit from burst tens.
Patients with knee pain due to OAk will be recruited through advertisements in local media.
Temporal summation, before and after a heterotopic noxious conditioning stimulation, will be measured.
In addition, pain on a numeric rating score, WOMAC subscores for pain and function and global perceived effect will be assessed.
Patients will be randomly allocated to one of two treatment groups (tens, sham tens).
Follow–up measurements will be scheduled after a period of 6 and 12 weeks.
Tens influences pain through the electrical stimulation of low–threshold A–beta cutaneous fibers.
The responsiveness of central pain–signaling neurons of centrally sensitized OAk patients may be augmented to the input of these electrical stimuli.
This would encompass an adverse therapy effect of tens.
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