Orthopedics News & Articles

1 Radiographic and patient-based outcome analysis of different bone-grafting techniques in the surgical treatment of idiopathic scoliosis with a minimum 4-year follow-up: allograft versus autograft/allograft combination The Spine Journal, May 14, 2013
Lansford TJ et al. - To determine if autograft in addition to allograft is associated with decreased healing period pain, increased early function, or both. The addition of autograft to allograft did not result in decreased pain or increased function at any time interval up to 4 years. Authors conclude that the addition of iliac crest autograft does not result in any advantage over freeze-dried allograft alone in the treatment of adolescent idiopathic scoliosis.

2 Chromoblastomycosis in a renal allograft recipient Indian Journal of Nephrology, May 15, 2013
Sooraj YS et al. - A 50-year-old lady presented with a progressive ulcero-proliferative lesion over the right heel for over 1 month. She was diagnosed with end-stage kidney disease 18 months earlier and had undergone a successful live-related renal transplantation 12 months ago. She was on prednisolone, cyclosporine, and mycophenolate mofetil. Ten months later, she developed severe allograft dysfunction, and renal allograft biopsy revealed acute humoral ...

3 γδTCR deficiency attenuated cardiac allograft vasculopathy and promoted regulatory T cell expansion Scandinavian Journal of Immunology, May 22, 2013
Zhu H, et al. - γδ T cell comprise about 5% of the overall T cell population and they differ from conventional αβ T cells. Previous papers have indicated the contribution of γδ T cell to acute allograft rejection, but the role of γδ T cell in cardiac allograft vasculopathy is not investigated. γδ TCR deficiency resulted in attenuated cardiac allograft vasculopathy and prolonged graft survival in murine models of cardiac ...

4 Frequent hepatocyte chimerism in long-term human liver allografts independent of graft outcome Transplant Immunology, February 7, 2013
Aini W et al. - The authors compared the proportions of recipient-derived hepatocytes in long-term stable liver allografts and late dysfunctional allografts caused by chronic rejection or idiopathic post-transplantation hepatitis. Through fluorescence in situ hybridization (FISH), the authors also analyzed the presence of recipient-derived Y-positive hepatocytes in the biopsies of livers transplanted from female donors to male recipients. In conclusion, ...

5 Effect of Peripheral Vascular Disease on Kidney Allograft Outcomes: A Study of U.S. Renal Data System Transplantation, March 22, 2013
Brar A et al. - The U.S. Renal Data System was used to analyze renal allograft outcomes in patients with peripheral vascular disease (PVD) at the time of transplant listing. Patients with PVD have inferior allograft and patient survival versus those without PVD. Caution should be exercised when placing patients with symptomatic PVD or amputation on the wait-list.

6 Effect of recombinant adeno-associated virus mediated transforming growth factor-beta1 on corneal allograft survival after high-risk penetrating keratoplasty Transplant Immunology, May 7, 2013
Zhou L et al. - Corneal transplantation is one of the most common and successful transplant surgeries performed around the world. The purpose of this paper is to investigate the effects and mechanisms of recombinant adeno-associated virus mediated transforming growth factor-beta1 (rAAV-TGF-beta1) on corneal allograft survival using a high-risk rat model after penetrating keratoplasty (PKP). Treatment with rAAV-TGF-beta1 prolongs corneal allograft ...

7 Tibiotalocalcaneal Arthrodesis With Bulk Femoral Head Allograft for Salvage of Large Defects in the Ankle Foot & Ankle International, May 8, 2013
Jeng CL et al. - This study examined the outcomes of tibiotalocalcaneal (TTC) arthrodesis using bulk femoral head allograft to fill this defect. Although the radiographic fusion rate was low, when the 7 patients who had an asymptomatic nonunion were combined with the radiographic union group, the overall rate of functional limb salvage rose to 71%. TTC arthrodesis using femoral head allograft should be considered a salvage procedure that is technically difficult and carries a high risk ...

8 Effect of Daily Sodium Intake on Post-transplant Hypertension in Kidney Allograft Recipients Transplantation Proceedings, May 9, 2013
Soypacaci Z et al. - Hypertension (HT) is a common problem, observed frequently after kidney transplantation due to several causes. Posttransplantation HT increases the incidence of both cardiovascular diseases and allograft failure. Although a low sodium diet is strongly advised, the relationship between it and posttransplantation HT has not been well studied in transplant patients. Daily sodium intake was extremely higher than recommended levels among kidney allograft recipients with ...

9 Renal allograft pathology in the sensitized patient Current Opinion in Organ Transplantation, May 23, 2013
Cornell LD - Patterns of renal allograft injury associated with alloantibody have been increasingly recognized over the past 2 decades. The use of more sensitive serum testing has brought to light the range of alloantibody-associated changes on biopsy at different time points posttransplant. There is likely to be an increasing number of patients with preformed alloantibody undergoing kidney transplantation, and so alloantibody-associated injury will become more prevalent. ...

10 Tissue biopsy monitoring of operational tolerance in liver allograft recipients Current Opinion in Organ Transplantation, May 23, 2013
Demetris AJ et al. - Highly selected, long-surviving, liver allograft recipients with normal/near normal liver injury tests can be weaned from immunosuppression. Baseline biopsies document changes before weaning and can help stratify risk of rejection or dysfunction after weaning; biopsies after weaning are used to study mechanisms of operational tolerance and to monitor for subclinical events. Operationally tolerant liver allograft recipients can be successfully managed with very ...