Orthopedics Medical News about Gene Expression

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Temporal pattern of gene expression and histology of stress fracture healing
Bone , 11/03/09

Kidd LJ et al. – There was significantly increased mRNA expression of RANKL and OPN. Prominent, upregulation of COX–2, VEGF, OPG, SDF–1, BMP–2, and SOST prior to peak expression of RANKL indicates the importance of these factors in mediating directed remodelling of the fracture line. Dramatic, early upregulation of IL–6 and IL–11 demonstrate their central role in initiating signalling events for remodelling and stress fracture healing.

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