Orthopedics

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Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
Osteoporosis International, 10/12/09

Breart G et al. – This study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients.

• Retrospective study
• Cohorts consisted of untreated osteoporotic women (N?=?11,546), osteoporotic women treated with alendronate (N?=?20,084), or strontium ranelate (N?=?2,408), and sample of non-osteoporotic women (N?=?115,009)
• Cohorts compared using Cox proportional hazards regression model

• Significantly increased relative risk for VTE in untreated osteoporotic women versus non-osteoporotic women (annual incidence 5.6 and 3.2 per 1,000 patient–years
• Results confirmed using adjusted models
• Annual incidences of VTE in osteoporotic patients treated with strontium ranelate and alendronate were 7.0 and 7.2 per 1,000 patient–years
• No significant difference between untreated and treated patients whatever the treatment
• Adjusted hazard ratios for treated versus untreated osteoporotic women 1.09 (95% CI, 0.60–2.01) for strontium ranelate and 0.92 (95% CI, 0.63–1.33) for alendronate

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