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See Latest ArticlesAssociation of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women
Journal of Bone and Mineral Metabolism, 10/19/09
Urano T et al. – HTRA1 (high–temperature requirement A1) has been implicated in the modulation of various disease pathologies. HTRA1 expression is upregulated in osteoarthritic joints, suggesting that it may contribute to the development of this debilitating disease. A genetic variation at the HTRA1 gene promoter locus is associated with spinal disc degeneration, suggesting an involvement of the HTRA1 gene in osteoarthritis.
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