Orthopedics Medical News about Raloxifene

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Raloxifene: its ossification-promoting effect on female mesenchymal stem cells
Journal of Orthopaedic Science, 10/08/09

Matsumori H et al. – 10–6 M Raloxifene had no ossification–inducing effect on female MSCs, but it had an ossification–promoting effect; it had no osteogenic effect on male MSCs. Therefore, raloxifene has a sex difference with regard to its osteogenic effect on MSCs. Moreover, combined treatment with raloxifene plus OS has an effect on female MSCs. These results provide a useful insight into the possible influence of raloxifene after MSC transplantation in clinical practice.

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