Orthopedics

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Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial
Osteoporosis International, 10/06/09

Eastell R et al. – Once-yearly ZOL increased hip and spine BMD vs placebo, assessed by QCT vs DXA. Changes in trabecular bone resulted in increased indices of compressive strength.

• Randomized, controlled trial of once-yearly ZOL
• 233 women
• lumbar spine, total hip, femoral neck, and trochanter assessed by DXA and QCT
• Mean percentage changes from baseline and between-treatment differences (ZOL vs placebo, t-test) evaluated

• Mean between-treatment differences for lumbar spine BMD were significant by DXA and QCT
• Between-treatment differences were significant for trabecular spine , trabecular trochanter ,total hip , and compressive strength indices at femoral neck , and trochanter

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