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See Latest ArticlesNotch signaling and the bone marrow hematopoietic stem cell niche
Bone , 09/23/09
Weber JM et al. – Reports have indicated that direct contact is necessary to mediate the osteoblastic effects and that these effects could be mediated through Notch activation. Notch signaling is important throughout development and also appears to play a critical role in cellular maturation and differentiation of osteoblastic cells and hematopoietic cells as disregulation can lead to bone loss and leukemias, respectively.
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