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Biological indicators of prognosis in Ewings sarcoma: An emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP)
International Journal of Cancer, 09/21/09

Zambelli D et al. – LGALS3BP as a novel reliable indicator of prognosis.

• Functional annotation of differentially regulated genes revealed 3 major networks related to cell cycle, cell-to-cell interactions and cellular development; the prognostic impact of 8 genes, representative of these 3 networks, was validated in 56 EWS patients

• High mRNA expression levels of HINT1, IFITM2, LGALS3BP, STOML2 and c-MYC were associated with reduced risk to death and lower risk to develop metastasis
• LGALS3BP, a matricellular protein with a role in tumor progression and metastasis, was the most important predictor of event-free survival and overall survival
• The association between LGALS3BP and prognosis was confirmed at protein level, when expression of the molecule was determined in tumor tissues but not in serum, indicating a role for the protein at local tumor microenvironment
• Engineered enhancement of LGALS3BP expression in EWS cells resulted in inhibition of anchorage independent cell growth and reduction of cell migration and metastasis
• Silencing of LGALS3BP expression reverted cell behavior with respect to in vitro parameters, thus providing further functional validation of genetic data obtained in clinical samples

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