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Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta analysis
Osteoarthritis and Cartilage , 09/18/09

Blagojevic M et al. – More longitudinal studies are needed to investigate the association of physical occupational and other patient-determined factors with future knee OA.E

Methods

A systematic literature search was carried out for cohort and case-control studies evaluating the association of demographic, comorbid, and other patient-determined factors with onset of knee OA
A scoring tool was developed to assess the quality of studies

Results

Of the 2233 studies screened, 85 were eventually included in the review
Study quality tended to be moderate
The main factors consistently associated with knee OA were obesity (pooled OR 2.63), previous knee trauma (pooled OR 3.86), hand OA (pooled OR 1.49), female gender (pooled OR 1.84), and older age
Smoking appeared to have a moderate protective effect

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