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Silverman SL – Zoledronic acid significantly reduced the risk of vertebral, nonvertebral, and hip fractures in postmenopausal women. Denosumab is a monoclonal receptor activator of nuclear factor–kB ligand antibody given by subcutaneous injection every 6 months that has been shown to significantly reduce risk of vertebral–, nonvertebral–, and hip fracture in postmenopausal women. Bazedoxifene, an estrogen agonist/antagonist, has significantly reduced the risk of vertebral fracture in postmenopausal women; a post hoc analysis showed reduction in risk of nonvertebral fracture in high–risk women.

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