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Knobloch K et al. – Antifibrotic medication using a combination of N–acetyl–L–cystein (NAC) and ACE inhibitor can prevent the recurrence of Dupyutren’s disease. Given the fact that recurrence rate in Dupuytren’s disease is high and unpredictable after surgical release, an antifibrotic intervention might be worthwhile to consider in the clinical setting. Antifibrotic agents inhibit TGF–beta1, which play a key role in fibromatosis.

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