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Hand deformities are important signs of disease severity in patients with early rheumatoid arthritis
Rheumatology, 09/03/09
Johnsson PM et al. – Presence of hand deformities had an impact on daily life function and added useful prognostic information, being an early sign of a more severe disease.
Methods- 183 patients with early RA
- Assessment of hand deformities was standardized. Hand mobility was measured by signals of functional impairment (SOFI), disability by HAQ and hand HAQ, disease activity by ESR and radiographic changes by the Larsen method
- One hundred and eight (59%) patients developed at least one hand deformity
- After 10 years, the rate of ulnar deviation, button hole deformity and swan neck deformity was 44, 24 and 23.5%, respectively
- The deformity group showed significantly higher disease activity during the first 5 years, and significantly more hand impairment, more disability and more severe radiographic changes throughout the study
- Presence of a deformity after 1 year increased the risk of developing a Larsen score above median after 5 years
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