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Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells
The Spine Journal, 08/25/09
Gruber HE et al. – Data showed that EGF is expressed and produced by annulus cells in vivo and in 3D culture, with significantly greater in vitro EGF produced in the presence of PGE1 or the PGE1 analog misoprostol. Misoprostol, developed for prevention/treatment of nonsteroidal anti–inflammatory–induced gastropathy, has now been reported to have some interesting anabolic effects stimulating osteoblasts during fracture healing and during ovariectomy in animal models.
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