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Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
Arthritis Research & Therapy, 08/25/09

Richardson SM et al.MMP-10 expression is increased in the symptomatic degenerate intervertebral disc, where it may contribute to matrix degradation and initiation of nociception.

Methods

Human nucleus pulposus (NP) tissue was obtained post-mortem from patients without back pain and graded as normal or degenerate
Symptomatic degenerate NP samples were also obtained at surgery for LBP
MMP-10 mRNA and protein expression was determined by PCR and immunochemistry
Gene expression for IL-1, TNF-alpha, NGF, and Substance P was determined

Results

MMP-10 mRNA was increased in surgical degenerate NP samples compared with normal and degenerate post-mortem samples
MMP-10 protein was increased in degenerate surgical NP samples compared to normal post-mortem samples
IL-1 and MMP-10 mRNA, but not TNF-alpha, had a significant correlation between surgical degenerate samples
NGF was significantly correlated with MMP-10 and Substance P mRNA in surgical degenerate NP samples

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