Orthopedics Medical News about 18F-FDG PET

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Prediction model of chemotherapy response in osteosarcoma by 18F-FDG PET and MRI
The Journal of Nuclear Medicine, 08/19/09

Cheon GJ et al. – Combined infomration of 18F-FDG PET and MRI scans, acquired before and after chemotherapy, could be used to predict histologic response to neoadjuvant chemotherapy in osteosarcoma.

Methods

70 consecutive patients with a high-grade osteosarcoma
Prospective study
All patients underwent 18F-FDG PET and MRI before and after neoadjuvant chemotherapy

Results

Patients with a SUV2 ≤ 2 had a good histologic response
Patients with a SUV2 > 5 had a poor histologic response
For patients with a SUV2 < 2 and ≤ 5, response was predicted by MVCR
A MVCR < 0.65 was a good responder; a MVCR ὅ 0.65 was a poor responder
The predictive values for good responders and poor responders were 97% and 95%, respectively

Exclusive Author Commentary
Dae-Geun Jeon, 08/19/09

As the PET image is an 3-dimensional value, the idea of combining the volume change during preoperative chemotherapy with PET value is the essence of this study. Furthermore, dividing any cohort into three group might reveal actual situation than binary grouping.

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