Orthopedics Medical News about Leptin, Synovial fluid, Osteoarthritis

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Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis
Clinical Rheumatology, 08/13/09

Ku JH et al. – Data demonstrate that synovial fluid (SF) leptin concentrations were closely related to the radiographic severity of osteoarthritis (OA), suggesting that SF leptin levels could be used as an effective marker for quantitative detection of OA.

Methods

An investigatiom of whether SF leptin level is related to the radiographic severity of OA and its role as a quantitative marker
SF was obtained from:
- 42 OA pts who underwent knee surgery, and
- 10 who had no abnormality of articular cartilage during arthroscopic examination
The progression of OA was classified by K/L grading scale
Concns of leptin were measured with commercial ELISA kits

Results

Median leptin concns in SF were higher in OA pts vs controls
SF leptin levels showed difference according to the severity of OA
Median SF leptin level was highest in stage IV pts which was higher vs other groups including controls
Age showed a positive correlation with leptin concns in OA pts, but not in controls

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