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Presence of Mycoplasma fermentans in the bloodstream of Mexican patients with rheumatoid arthritis and IgM and IgG antibodies against whole microorganism
BMC Musculoskeletal Disorders, 08/06/09

Gil C et al. – Study shows that only Mycoplasma fermentans produce bacteremia in a high percentage of patients with RA. IgM and IgG against M. fermentans PG18 were more frequent in patients with RA than healthy individuals

• Aim was to investigate M. fermentans in the bloodstream of RA pts
• 219 blood samples from pts with RA, SLE, antiphospholipid syndrome, and healthy individuals were screened by bacterial culture and direct PCR in order to detect mycoplasmas
• IgM and IgG against M. fermentans PG18 were also detected by ELISA and Immunoblotting assays

• Blood samples from pts with antiphospholipid syndrome and healthy individuals were negative for mycoplasma by culture or direct PCR
• In blood samples from pts with SLE were detected by direct PCR M. fermentans in 2%, M. hominis in 2% and U. urealyticum in 0.5 %
• In pts with RA M. fermentans was detected by culture in 13/87 blood samples and in 13/87 by direct PCR
• However, there was only concordance between culture and direct PCR in 6 samples, so M. fermentans was detected in 23% of the blood samples from pts with RA by either culture or PCR
• Antibody-specific ELISA assay to M. fermentans PG18 was done:
  • IgM was detected in sera from 40/87 pts with RA and in sera of 7/67 controls
  • IgG was detected in sera from 48/87 RA pts and in sera from 7/67 healthy individuals
• Antibody-specific immunoblotting to M. fermentans PG18 showed IgM in sera from 35/87 pts with RA and in sera from 4/67 healthy individuals
• IgG was detected in sera from 34/87 pts and in sera from 5/67 healthy individuals

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