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Chappell AS et al. – Herein, the authors report the results of a 13–week, randomized, double–blind, placebo–controlled trial of duloxetine (60–120mg/day) versus placebo in the treatment of knee pain in 231 patients meeting clinical and radiographic criteria for osteoarthritis of the knee. Duloxetine was superior to placebo on the primary efficacy measure (weekly mean 24–h pain scores) beginning at Week 1 and continuing through the treatment period. There was also a significant improvement in the WOMAC physical functioning subscale and several other secondary outcomes. Adverse–event rates did not differ significantly between treatment groups (49.5% for duloxetine 60–120 mg/day, and 40.8% for placebo).
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