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See Latest ArticlesPrimary lymphoma of the bone mimicking metastatic carcinoma: Importance of a systematic approach
Journal of Orthopaedics, 07/29/09
Song JY et al. – In a case study of a pt with multiple bone lytic lesions who by clinical, radiologic, and morphologic evidence appeared to have metastatic carcinoma, this report illustrates the necessity of radiologic and morphologic correlation in establishing the correct diagnosis. Primary bone lymphoma (PBL) can infrequently involve multiple bones of the pelvis in the absence of a soft tissue mass or regional lymphadenopathy with an associated carcinoma-like desmoplastic response.
Methods- MRI revealed lesions in the right ilium, right sacroiliac joint, right proximal femur, left ilium, and left side of the sacrum.
- Both CT and MRI did not disclose any soft tissue mass or lymphadenopathy.
- Biopsy of the left posterior iliac crest showed a high-grade undifferentiated neoplasm with a marked desmoplastic response.
- Only after exclusion of non-hematopoietic neoplasms by an extended immunohistochemical panel was the diagnosis of PBL, centroblastic variant, made.
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