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Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on A771726 pharmacokinetics in leflunomide treated patients with rheumatoid arthritis
Drug Metabolism and Disposition, 07/07/09
Grabar PB et al. - Results suggest that genetic variability in leflunomide-metabolizing enzymes influence leflunomide metabolite concentrations that are associated with the treatment response, but not with leflunomide-induced toxicity.
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