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See Latest ArticlesFunctional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism
Arthritis & Rheumatism, 07/10/09
Egli RJ et al. - The findings show that the OA susceptibility mediated by polymorphism in GDF5 is not restricted to cartilage, emphasizing the need to consider the disease as involving the whole joint. The existence of an additional cis-acting regulatory polymorphism highlights the complexity of the regulation of expression of this important OA susceptibility locus. DEAF-1 is a trans-acting factor that merits further investigation as a potential tool for modulating GDF5 expression.
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