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Comparison of quantitative imaging of cartilage for osteoarthritis
Magnetic Resonance Imaging , 06/24/09

Taylor C et al. – Findings suggest that T1ρ, T2 and contrast-enhanced techniques may provide complementary information about the molecular environment in cartilage during the evolution of osteoarthritis (OA).

Methods

Study highlights the differences between various approaches to assess biochemical markers of cartilage integrity in degenerative joint diseases such as OA
A comparison of MRI (T1, T2 and T1ρ) and contrast-enhanced CT in human articular cartilage, in presence and absence of gadolinium (Gd)-based contrast agent was carried out

Results

Pre- and postcontrast T2 values were similar on a regional level and correlated with each other
T1 values were shortened on both a global and a spatial basis in the presence of Gd
Similar results were found for T1ρ
T2 values correlated mildly with postcontrast T1, T1(Gd) and with precontrast T1ρ values
In addition, contrast-enhanced CT values correlated with both precontrast T1ρ and T1(Gd) more strongly than with precontrast T2
Finally, T1(Gd) and precontrast T1ρ were moderately correlated with CT data
However, T1(Gd) and precontrast T1ρ were completely uncorrelated

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