Orthopedics Medical News about biochemical markers;bone turnover

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Laboratory reproducibility of biochemical markers of bone turnover in clinical practice
Osteoporosis International, 06/18/09

Schafer AL et al. - Study concludes that reproducibility of urine N-telopeptide (NTX) and serum bone-specific alkaline phosphatase (BAP) varies substantially across US labs.

Methods

An assessment of the laboratory reproducibility of urine NTX and serum BAP
Identical specimens of serum and urine from 5 postmenopausal women were sent to 6 US commercial labs on 5 dates over an 8-mo period
To evaluate within-run reproducibility, on the fifth date, each lab was sent 5 identical specimens
Labs were unaware of the investigation

Results

Longitudinal coefficients of variation (CVs) ranged from 5.4% to 37.6% for NTX
CVs ranged from 3.1% to 23.6% for BAP
Within-run CVs ranged from 1.5% to 17.2% for NTX
Compared to the Osteomark NTX assay, the Vitros ECi NTX assay had higher longitudinal reproducibility and within-run reproducibility

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