Orthopedics Medical News about previous malignancy;primary malignant tumors;bone

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Primary malignant tumours of bone following previous malignancy
Sarcoma, 06/12/09

Patton JT et al. - In a study to emphasise the necessity for caution in assuming the diagnosis of a metastasis when a solitary bone lesion is identified following a prior malignancy, it was concluded that inappropriate biopsy and treatment of primary bone sarcomas compromises limb salvage surgery and can affect pt mortality.

Methods

Destructive bone lesions occurring in pts who have previously had a malignancy are generally assumed to be a metastasis from that malignancy.
60 pts were reviewed with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone.

Results

These second malignancies occurred in 3 distinct groups of pts: pts with original tumours well known to be associated with second malignancies (5%); pts whose second malignancies were likely to be due to previous treatment of their primary malignancy (40%); pts in whom there was no clearly defined association between malignancies (55%).

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