Your Article Summary
See Latest ArticlesDetection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT
European Journal of Nuclear Medicine & Molecular Imaging, 06/09/09
Krüger S et al. - In a study to compare diagnostic accuracy of 18F-fluorodeoxyglucose (FDG) PET/CT vs standard planar bone scintigraphy (BS) and 18F-labelled NaF (18F) PET for detection of bone metastases (BM) in non-small cell lung cancer (NSCLC), it was concluded that integrated 18F-FDG PET/CT is superior to BS in detection of osteolytic BM in NSCLC. PET/CT may obviate the need to perform additional BS or 18F PET in staging of NSCLC, which significantly reduces costs.
Methods- 18F-FDG PET/CT was performed in 126 pts with NSCLC.
- Within 7 days BS (n=58) or 18F PET (n=68) was performed.
- 18F-FDG PET/CT, BS and 18F PET were evaluated by 2 experienced readers.
- Lesions were graded on a scale from 1 (definite BM) to 5 (degenerative lesion), and equivocal lesions were determined as indifferent (grade 3).
- 92 pts showed degenerative lesions (grade 4/5) on PET/CT, BS or 18F PET.
- In 34 pts (27%), BM lesions were diagnosed (grades 1 and 2).
- In 13 of 18 pts, BM were concordantly diagnosed with PET/CT and 18F PET.
- PET/CT showed more BM vs 18F PET (53 vs 40).
- In 1 pt, 1 osteolytic BM was false-negative on 18F PET.
- 18F PET identified 4 pts with BM compared with negative findings on PET/CT.
- Of 16 pts, 11 had concordant findings of BM on PET/CT and BS.
- In 3 pts, BS was false-negative and in 2 pts BM were diagnosed as indifferent.
Today in Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
A phase 2 trial exploring the effects of high-dose (10,000 IU/day) Vitamin D3 in breast cancer patients with bone metastases
Cancer, 11/25/09
Endoprosthetic proximal femur replacement: Metastatic versus primary tumors
Surgical Oncology, 11/05/09
Survival in high-grade osteosarcoma: improvement over 21 years at a single institution
Annals of Oncology, 11/16/09
Today in Radiology/Diagnostics...keeping you current
Receive free subspecialty "5-minute updates" via email
Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09
Imaging of Back Pain in Children
American Journal of Neuroradiology, 11/23/09
Evaluation of occipitocervical subluxation in rheumatoid arthritis patients, using coronal-view reconstructive computed tomography
Spine, 11/16/09