Orthopedics Medical News about osteosarcoma cells;proliferation inhibition effect;docetaxel combined with cisplatin

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Proliferation inhibition effect of docetaxel combined with cisplatin on osteosarcoma cells
Medical Oncology, 06/10/09

Jin W et al. - In a trial to examine the proliferation inhibition effect of combined use of docetaxel and cisplatin on osteosarcoma cells, it was concluded that the combined use of docetaxel and cisplatin is more effective than either of the drugs used alone in inhibiting the proliferation of osteosarcoma cells.

Methods

The effects of docetaxel and cisplatin used alone and combined on osteosarcoma cell line HOS8603 were examined by means of cell count, morphologic observation, and flow cytometry (FCM).

Results

Docetaxel and cisplatin either used alone or in combination, significantly inhibited the proliferation of osteosarcoma cells and apparently induced the apoptosis.
The effect of the combined drugs was better than that of the drugs used alone.

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