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See Latest ArticlesAdherence to monthly and weekly oral bisphosphonates in women with osteoporosis
Osteoporosis International, 05/27/09
Cotte FE et al. - Adherence to bisphosphonates may be superior for monthly treatment than for weekly treatment and may thus provide improved fracture protection.
Methods- Study to evaluate whether monthly bisphosphonate treatment provided superior adherence than weekly treatment.
- Medical claims from a national prescription database was analysed
- All women aged >45 yrs receiving a first prescription of monthly ibandronate or weekly bisphosphonates in 2007 were included
- Treatment adherence was monitored from initial prescription until Jan 2008
- Compliance: measured by medication possession ratio (MPR)
- Persistence: by the time from treatment initiation to discontinuation
- Multivariate analysis used to identify variables independently associated with adherence
- 12-mo persistence rates were 47.5% for monthly ibandronate and 30.4% for weekly bisphosphonates
- Compliance was significantly higher in the monthly cohort than in the weekly cohort
- Women with monthly regimens were 37% less likely to be non-persistent and presented a 5% higher mean MPR than women with weekly regimens
- Other major factors associated with improved adherence: previous densitometry and calcium or vit D supplementation
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