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See Latest ArticlesLSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
Genes, Chromosomes and Cancer, 05/18/09
Kresse SH et al. – Study shows that limbic system-associated membrane protein (LSAMP) is a novel candidate tumor suppressor gene in osteosarcomas.
Methods- An analysis of the karyotype in osteosarcomas
- DNA copy number changes in 36 osteosarcoma tumors and 20 cell lines were examined using microarray-based comparative genomic hybridization
- Chromosomal deletion was validated using FISH
- Expression level and promoter methylation status were investigated using qRT-PCR and methylation-specific PCR, respectively
- Most frequent minimal recurrent regions of gain identified in the tumor samples were in 1q21.2-q21.3, 1q21.3-q22, and 8q22.1
- Minimal recurrent regions in 10q22.1-q22.2, 6q16.1, 13q14.2, and 13q21.1 were most frequently lost
- A small region in 3q13.31 (2.1 Mb) containing the gene LSAMP (a tumor suppressor gene) was frequently deleted
- LSAMP showed low expression in 6/15 tumors and 5/9 cell lines with deletion of 3q13.31
- Low expression also seen in 5/14 tumors and 3/11 cell lines with normal copy number or gain
- Partial or full methylation of the investigated CpG island was identified in 3/30 tumors and 7/20 cell lines
- Loss of 11p15.4-p15.3 and low expression of LSAMP were associated with poor survival
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