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See Latest ArticlesRecombinant bone morphogenic protein-2 in orthopaedic surgery: a review
Archives of Orthopaedic and Trauma Surgery, 03/18/09
Valdes MA et al. - Bone morphogenic proteins (BMPs) are pleiotropic regulators of bone volume, skeletal organogenesis and bone regeneration after a fracture. They function as signaling agents to affect cellular events like proliferation, differentiation and extracellular matrix synthesis. Clinically utilized rhBMP-2 combines rhBMP-2 with an osteoconductive carrier to induce bone growth and acts as a bone graft substitute. rhBMP-2, initially released in 2002, has been used primarily in spinal fusions in the lumbar and cervical regions.
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