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Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case–control population (the GOAL study)
Osteoarthritis and Cartilage , 02/23/09

Limer KL et al. - Lack of replication is common and could be due to differences in study design, phenotype, populations examined or the occurrence of false positives in the initial study. Variants within TGFB1, IGF1 and IL1RN could have a role in OA susceptibility; however, replication of these findings is required in an independent study.

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