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See Latest ArticlesWnt signaling and the regulation of bone mass
Current Osteoporosis Reports, 02/13/09
Baron R et al. - In what may be a novel paradigm, the ubiquitous nature of LRP5/6 and Wnt signaling is counterbalanced by the bone-restricted and regulated expression of Wnt antagonists such as sclerostin and Dickkopf-1 in adult tissues, offering new and potentially safe therapeutic means of intervention to stimulate bone formation.
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